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Updated: Jun 26, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

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一种对温度敏感的脂质体1H CEST和19F对比剂,用于MR图像引导药物输送

Sander Langereis1, Jochen Keupp, Juliën L J van Velthoven

  • 1Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands. sander.langereis@philips.com

Journal of the American Chemical Society
|January 29, 2009
PubMed
概括

一种新的温度敏感的脂质体MRI对比剂使得药物载体的精确追踪和释放量化成为可能. 这项创新使用质子化学交换和转移 (CEST) 和-19磁共振成像用于局部温度触发的药物递送监测.

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Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.