不对称的C2-C3环的环化
José Barluenga1, Eva Tudela, Alfredo Ballesteros
1Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
Journal of the American Chemical Society
|January 30, 2009
概括
石化 (((0) 碳化合物复合物促进了 [3+2] 循环反应. 这一过程高效地合成了在酶体上纯净的英和四二二烯融合的环二烯.
科学领域:
- 有机金属化学 有机金属化学
- 有机合成 有机合成
- 不对称的催化剂.
背景情况:
- 石化碳化合物复合物是有价值的合成中间体.
- 在复杂分子合成过程中,培养酶选择性循环反应至关重要.
研究的目的:
- 为了研究的 [3+2] 循环化合性非血糖基基基基基基基基基基基基基基基化合物基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基
- 为了合成合的环丁骨,以酶丰富丰富.
主要方法:
- 使用的性非血性基基基基基基基基化合物复合物.
- 进行了 [3+2] 循环化反应.
- 通过使用奇拉色谱,分析产品以探测对比分子纯度.
主要成果:
- 成功合成了α-methylindoles和1,6-dimethyl-1,2,3,4-tetrahydropyridine衍生物. 已经成功合成了α-methylindoles和1,6-dimethyl-1,2,3,4-tetrahydropyridine衍生物. 已经成功合成了α-methylindoles和1,6-dimethyl-1,2,3,4-tetrahydropyridine衍生物.
- 形成了2,3 - 印度林融合的环二烯和2,3 - 皮佩里丁融合的环二烯骨架.
- 获得的产品具有非常高的反体纯度,范围为96-99% ee.
结论:
- 化 (((0) 碳化合物复合物是对enantioselective [3+2] 循环的有效催化剂.
- 这种方法提供了一条直接通往化环二烯系统的途径.
- 高等离子过量证明了这种方法在不对称合成中的实用性.
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