复制基因的不同进化导致A. thaliana内部的遗传不相容性
David Bikard1, Dhaval Patel, Claire Le Metté
1Genetics and Plant Breeding, INRA, SGAP UR254, F-78026 Versailles, France.
概括
在Arabidopsis thaliana中的基因相互作用导致胚胎致死性,这是由于重复基因的演变变异. 这凸显了基因重复和损失如何驱动物种间的遗传不相容性和物种化.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 植物科学 植物科学
背景情况:
- 后结节障碍对物种化至关重要.
- 遗传不兼容性可能是由于局部相互作用引起的.
- 这些不相容性可能会阻碍跨物种交叉.
研究的目的:
- 调查导致Arabidopsis thaliana胚胎致死性的表皮相互作用.
- 确定差异进化在基本重复基因的类似物中的作用.
- 了解基因重复和灭绝对遗传不相容性的贡献.
主要方法:
- 在Arabidopsis thaliana菌株之间进行交叉繁殖实验.
- 分析特定位置之间的表皮性相互作用.
- 检查基因对象的进化轨迹.
主要成果:
- 确定了控制Arabidopsis交叉中的衰退胚胎致死性的表观相互作用.
- 一个基本的重复基因的类基因的不同进化解释了这些不相容性.
- 基因的功能副本在不同的接入处不一致,导致异质性.
结论:
- 基因重复和灭绝是遗传不相容性的重要驱动因素.
- 这些被动进化机制导致了菌株之间广泛的不相容性.
- 这种不相容性可能是多种类型中物种化的根本来源.
相关概念视频
Gene Duplication and Divergence
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Gene Families
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Convergent Evolution
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
Gene Conversion
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...


