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住院患有传染性内心炎的儿童的特征
Michael D Day1, Kimberlee Gauvreau, Stanford Shulman
1Department of Cardiology, Children's Hospital Boston and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Circulation
|February 4, 2009
概括
儿科感染性内心炎 (IE) 正在向没有心脏病的儿童转移. 患有IE的儿童死亡的危险因素包括先天性心脏病,早产和金黄色葡萄球菌感染.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 儿童感染性内心炎 (IE) 是一种罕见的疾病.
- 大多数关于儿科IE的现有数据来自专门的转诊中心.
- 这项研究旨在描述广泛的国家儿科样本中的IE特征.
研究的目的:
- 评估儿童感染性内心炎的流行病学特征.
- 确定与儿科IE相关的趋势和风险因素.
- 分析儿科IE病例的结果和死亡率.
主要方法:
- 从儿童住院患者数据库 (2000年和2003年) 中分析医院出院记录.
- 纳入标准:年龄在21岁以下的患者,IE诊断代码.
- 对两年数据的综合分析.
主要成果:
- 总共分析了1588例儿童IE住院病例.
- 年龄分布显示在婴儿期和青春期晚期的峰值.
- 黄金葡萄球菌是最常见的病原体 (57%),其次是维里丹斯链球菌 (20%).
- 42%的患者有先前存在的心脏病,主要是先天性心脏病 (81%).
- 住院死亡率为5% (84名患者),特定的先天性心脏缺陷和假内心炎的比率更高.
- 在没有先前存在心脏病的死亡人数中,金黄色细菌在较大的儿童中普遍存在,而早产是婴儿的因素.
结论:
- 儿科IE流行病学显示,没有先前存在的心脏病的病例增加的趋势.
- 先天性心脏病和假内心炎是死亡的重要风险因素.
- 在非先天性心脏病病例中,早产/新生儿年龄和金黄色细菌感染是关键的死亡率预测因素.
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