相关实验视频
禁食血糖和中风和心肌梗塞的风险
Joohon Sung1, Yun-Mi Song, Shah Ebrahim
1Department of Epidemiology, the Graduate School of Public Health, and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Circulation
|February 4, 2009
概括
禁食血糖 (FBG) 升高会增加缺血性中风风险,甚至低于糖尿病水平. 高FBG也会增加心肌梗塞和出血性中风的风险,但不如之前认为的那么显著.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病是动脉样硬化心血管疾病的已知危险因素.
- 与低于糖尿病值的血糖相关的心血管疾病风险尚不清楚.
研究的目的:
- 调查韩国一大批男性的空腹血糖 (FBG) 水平与心血管疾病 (CVD) 风险之间的关联.
- 确定FBG水平低于目前的糖尿病值是否会造成心血管疾病事件的风险,特别是中风和心肌梗塞.
主要方法:
- 一组652,901名韩国男性 (30-64岁) 根据基线FBG水平被分为8组.
- 从1992年至2001年,参与者被跟踪心血管疾病的发生,包括中风和心肌梗塞.
- 经过对年龄,社会经济地位,行为和其他心血管疾病风险因素进行调整的统计分析.
主要成果:
- 在经过年龄调整的分析中,观察到FBG和心肌梗塞,缺血性中风和脑内出血性中风之间存在线性关联.
- 在完全调整后,心肌梗塞和脑内出血性中风的相关性减弱,只有在最高FBG水平 (≥7.5 mmol/L) 时,风险增加.
- 在完全调整后,FBG和缺血性中风之间的关联仍然存在,显示FBG水平为5.6 mmol/L的风险线性增加.
结论:
- 高FBG和心血管疾病风险之间的关联在缺血性中风,脑内出血性中风和心肌梗塞之间有所不同.
- 在FBG水平低于受损的禁食葡萄糖标准 (≥5.6 mmol/L) 的情况下,观察到缺血性中风风险的线性增加,独立于其他风险因素.
- 目前糖尿病的诊断切断有效地识别了韩国男性患心肌梗塞和脑内出血性中风的风险.
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