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相关概念视频

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

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Cargo Loading onto Kinesin Powered Molecular Shuttles
09:00

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

一个带有光门的STOP-GO分子航天器.

Ali Coskun1, Douglas C Friedman, Hao Li

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Journal of the American Chemical Society
|February 6, 2009
PubMed
概括

研究人员使用光操作的门设计了分子航天器. 通过将甲基或基结合到阿佐比基单元中,他们控制了航天飞机.

科学领域:

  • 超分子化学 超分子化学
  • 分子机器 分子机器
  • 摄影化学的使用.

背景情况:

  • 退化 [2] 罗塔克桑具有动态平衡的特征,具有用于穿的低激活能量障碍.
  • 减速器 (静态/静电屏障) 可以显著增加这些能源屏障.
  • 4,4'-azobiphenyloxy (ABP) 单元在分子系统中提供了作为响应光的门的潜力.

研究的目的:

  • 通过修改ABP单元来设计光控制的分子航天器.
  • 为了研究固体 (甲基) 和电子 (原子) 修改对穿门功能的影响.
  • 用光和热能证明精确控制分子航天器动力学.

主要方法:

  • 合成的ABP衍生物具有四个甲基组 (ABP-Me) 和四个原子 (ABP-F).
  • 利用紫外线和可见光调节门的状态.
  • 研究了在不同的光照条件下对穿过程的自由激活能量 (DeltaG‡).

主要成果:

  • ABP-Me(4) 导致一个永久关闭的门,表明有效的立体障碍.
  • ABP-F(4) 显示了可切换光的行为:被紫外线照射而关闭,被可见光照射而打开.
  • 光被证明可以反向控制自由能量屏障,使"STOP"和"GO"状态.

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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
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Published on: November 25, 2015

结论:

  • 针对ABP单元的定制修改允许创建可光定位的分子门.
  • 对固态和电子性质的光化学控制使分子穿运动的动态调节成为可能.
  • 这项研究为开发具有可编程功能的先进分子机器提供了途径.