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相关概念视频

The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action potential...
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...
Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...

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相关实验视频

Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

迪内因开始起作用.

Anne Houdusse1, Andrew P Carter

  • 1Structural Motility Team, Institut Curie, Centre de Recherche, Paris, France.

Cell
|February 11, 2009
PubMed
概括

迪内因运动蛋白质将化学能量转化为机械力,用于运动. 这项研究揭示了dynein的结构安排.

科学领域:

  • 分子生物学分子生物学
  • 细胞力学 细胞力学
  • 生物化学 生物化学

背景情况:

  • 运动蛋白质是必不可少的分子机器,将化学能量转化为机械工作.
  • 迪尼因是一种关键的运动蛋白,参与细胞内运输和运动.
  • 了解运动蛋白质中产生力量的机制对于细胞生物学来说至关重要.

研究的目的:

  • 为了阐明dynein运动域内的子域的结构安排.
  • 提出一个功能模型,用于dynein介导的力量产生.

主要方法:

  • 对dynein运动领域的结构分析.
  • 生物化学试验研究ATP水解和力产生.

主要成果:

  • 详细描述dynein动力域中子域的特定排列方式.
  • 一个拟议的模型说明了这些子域在产生力方面协调的功能.

结论:

  • 亚域的特定排列对于dynein的运动功能至关重要.
  • 拟议的模型提供了对dynein产生力量的分子机制的见解.

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Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
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Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

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Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
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Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

相关实验视频

Last Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
07:18

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019