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只有PH域的蛋白质PHLDA3是Akt的p53调节抑制剂

Tatsuya Kawase1, Rieko Ohki, Tatsuhiro Shibata

  • 1Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan.

Cell
|February 11, 2009
PubMed
概括

瘤抑制剂p53激活PHLDA3,从而抑制了Akt的信号传输. 失去PHLDA3促进癌症生长,揭示了p53和Akt之间的瘤抑制的新联系.

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