在患有大动脉狭窄症的患者中,对运动的系统性动脉反应
Warren K Laskey1, William G Kussmaul, Abraham Noordergraaf
1Division of Cardiology, Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA. warrenlaskey@earthlink.net
Circulation
|February 11, 2009
概括
患有大动脉狭窄症 (AVS) 的患者表现出动脉负载和硬度增加,导致运动期间中风输出响应减少. 这种动脉硬化是AVS观察到的运动能力下降的关键因素.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 临床血液动力学 临床血液动力学
背景情况:
- 系统性动脉血动力学对于评估大动脉狭窄症 (AVS) 的严重程度和后果至关重要.
- 了解AVS中的动脉负载对于管理患者的结果至关重要.
研究的目的:
- 为了研究静止和运动期间AVS患者的系统性动脉血液动力学特性.
- 确定动脉负载对AVS运动反应减弱的贡献.
主要方法:
- 获得了上升的大动脉压力和血液流动速度的高保真导管记录.
- 在18名AVS患者和11名对照中,在休息状态和躺着骑自行车运动期间进行了测量.
- 计算了全身血管阻力,动脉顺应,动脉弹性和大动脉特征阻抗.
主要成果:
- 与对照人群相比,AVS患者的系统血管抵抗,动脉弹性和静止时大动脉特征阻抗增加.
- 静止状态下AVS患者的整体动脉合性较低,并且与运动没有增加,与对照组不同.
- 运动导致AVS患者的动脉弹性增加,而中风流量增加减弱.
结论:
- 患有AVS的患者有稳定和脉动动脉的动脉负载成分升高,独立于压力.
- 在AVS中,持续的动脉硬化显著导致中风输出对运动的反应受损.
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