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Updated: Jun 25, 2026

PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
09:31

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Published on: September 26, 2020

人类二氧化原酶中的基质蛋白相互作用:H76的关键作用

Dipanwita Batabyal1, Syun-Ru Yeh

  • 1Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, usa.

Journal of the American Chemical Society
|February 13, 2009
PubMed
概括

在人类二氧化三二氧化酶 (hTDO) 中研究histidine 76 (H76) 揭示了其作为活性基位基的关键作用. 突变H76S和H76A通过破坏催化和基质结合,显著损害了酶活性.

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