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一个ABC输送器控制了Drosophila生殖细胞吸引剂的出口
1Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA.
Science (New York, N.Y.)
|February 14, 2009
概括
定向细胞迁移依赖于化学吸引力. 这项研究揭示了多索菲拉菌的生殖细胞使用一种独特的途径,类似于酵母,以分泌脂质修饰的,突出了细胞信号传递中的保存机制.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
- 生物化学 生物化学
背景情况:
- 定向细胞迁移对于发育和疾病至关重要,它依赖于化学吸引剂信号传递.
- 化学吸引剂通常通过经典途径分泌,但脂质修饰吸引剂需要其他机制.
- 发芽酵母利用一个信号独立的途径,涉及一个ABC转运器,以分泌法化激素.
研究的目的:
- 研究Drosophila生殖细胞迁移中化学吸引剂分泌的机制.
- 为了确定多索菲拉菌的生殖细胞是否使用类似于酵母的途径来分泌脂质修饰的.
- 探索跨物种的这种非常规出口途径的保护.
主要方法:
- 对多菌生殖细胞迁移路径的分析.
- 研究脂质修饰和化学吸引剂的分泌.
- 与酵母激素分泌途径进行比较分析.
主要成果:
- 德洛索菲拉菌的生殖细胞被脂质修饰的素所吸引.
- 一个信号独立的途径,涉及保存的成分,介导这些吸引剂的分泌.
- 这条路径与发芽酵母用于激素分泌的路径相似.
结论:
- 无脊椎动物的生殖细胞利用一种保守的,非常规的途径来分泌脂质修饰的化学吸引剂.
- 这种涉及ABC载体的机制与酵母中发现的类似.
- 这个途径的保存性表明它在调节从酵母到人类的化学吸引剂生产中的重要性.
相关概念视频
01:31ABC Transporters: Exporter
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
01:27ABC Transporters: Importer
ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types: