直接催化不对称的添加化酸的酸
Ryo Yazaki1, Naoya Kumagai, Masakatsu Shibasaki
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Journal of the American Chemical Society
|February 14, 2009
概括
这项研究引入了一种新的催化方法,用于对酸和酸进行不对称的添加. 该过程产生了光学丰富的三级醇与Z配置的不和利,展示了广泛的基质范围.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 在有机合成中,开发有效的方法来制造性三级醇至关重要.
- 对碳化合物的不对称加法反应是产生立体中心的关键转换.
- 化是一种多用途的构建块,但其直接不对称的添加到子仍然具有挑战性.
研究的目的:
- 开发一种新型的直接催化不对称的化与酸的添加方法.
- 为了在产品中实现独家的玛添加和高的酶选择性.
- 探索开发的催化系统的基质范围和一般性.
主要方法:
- 使用了一种双金属催化系统: (R,R) -Ph-BPE/[Cu(CH3CN) [4]ClO4/LiOAr.
- 采用了柔软的易斯酸/硬的布伦斯特基双功能催化剂的质子转移条件.
- 研究了与各种芳香,异芳香和异芳香的反应.
主要成果:
- 实现了酸与酸的独家玛添加.
- 合成的光学丰富的三级酒精含有Z配置的α,β不和利.
- 证明了广泛的基质通用性,包括芳香,异芳香和酸.
结论:
- 开发的双金属催化系统为不对称的化的玛添加提供了一条有效的途径.
- 这种反应提供了一种有价值的方法,可以获得具有有价值的不和酸盐功能的奇拉三级酒精.
- 该方法的广泛基质适用性突出显示了其对各种合成应用的潜力.
相关概念视频
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