咖啡消费与女性中风风险的关系
Esther Lopez-Garcia1, Fernando Rodriguez-Artalejo, Kathryn M Rexrode
1Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA. esther.lopez@uam.es
Circulation
|February 18, 2009
概括
咖啡消费可能会降低女性中风风险. 长期摄入并没有与中风发病率的增加有关,这表明潜在的保护作用,特别是在非吸烟者中.
科学领域:
- 流行病学 流行病学
- 心血管疾病研究研究
- 营养科学 营养科学
背景情况:
- 关于咖啡消费与中风风险之间的联系的数据有限.
- 这项研究调查了女性在24年随访期间的咖啡摄入量和中风风险.
研究的目的:
- 评估长期咖啡消费与大批女性中风发病率之间的关系.
- 为了确定咖啡消费是否与中风风险的增加或减少有关.
主要方法:
- 来自护士健康研究 (1980-2004) 的83,076名女性的前性队列研究.
- 定期评估咖啡消费;记录了中风事件 (出血,缺血,未确定).
- 使用多变量考克斯回归模型,根据许多生活方式和健康因素进行调整.
主要成果:
- 较高的咖啡消费量 (≥4杯/天) 与中风风险降低有关 (RR=0.80).
- 反向关联是显著的 (P为趋势=0.003) 并且在调整高血压,高胆固醇和糖尿病后仍然存在.
- 与目前吸烟者相比,在从未吸烟和过去吸烟者中,保护性关联更强.
结论:
- 长期饮用咖啡与女性中风风险增加无关.
- 咖啡消费可能与中风风险的适度降低有关.
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