假设的ABC转运器使小麦对多种真菌病原体产生持久的耐药性
Simon G Krattinger1, Evans S Lagudah, Wolfgang Spielmeyer
1Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland.
Science (New York, N.Y.)
|February 21, 2009
概括
小麦基因Lr34提供了对真菌病原体的持久性抗病能力. 该基因的功能类似于药物载体,其变异影响植物耐药性,促进叶子衰老.
科学领域:
- 植物病理学 植物病理学
- 分子遗传学 分子遗传学
- 农业科学 农业科学
背景情况:
- 持久的抗病能力对于作物长寿和产量至关重要.
- 小麦易受破坏性真菌病原体的影响,如生和粉.
- Lr34基因在全球小麦品种中提供了超过50年的耐药性.
研究的目的:
- 阐明Lr34基因在赋予持久性疾病耐药性的分子机制.
- 为了确定负责Lr34介导的耐药性或易感性的遗传变异.
- 了解Lr34如何影响植物生理学对病原体的反应.
主要方法:
- 生物信息分析以确定LR34蛋白的功能类.
- 对抗性和易受性Lr34等位基因的比较基因分析.
- 对成年植物Lr34功能的表型分析,重点关注旗叶衰老.
主要成果:
- 该LR34蛋白被确定为一种腺三酸盐结合盒 (ABC) 载体,属于类药物耐药性 (PDR) 亚家族.
- 三种特定的遗传多态性区分了Lr34基因基因,这些基因基因基因赋予了耐药性,而不是那些赋予了易感性.
- Lr34基因在旗叶中激活了类似衰老的过程,特别是在尖端和边缘,有助于抵抗疾病.
结论:
- Lr34作为PDR载体起作用,为其在疾病抵抗中的作用提供了分子基础.
- 了解Lr34中的遗传多态性可以帮助培育具有增强和持久的抗病能力的小麦品种.
- 由Lr34诱导叶子衰老是一个关键的机制,有助于其对真菌病原体的保护作用.
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