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富含白的重复蛋白质复合物激活蚊子补充剂,以防范菌寄生虫

Michael Povelones¹, Robert M Waterhouse, Fotis C Kafatos

¹Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

Science (New York, N.Y.)

|March 7, 2009

概括

两种蚊子蛋白,LRIM1和APL1C,形成一个复合体,针对疟疾寄生虫进行破坏. 这一发现有助于我们更好地了解Anopheles gambiae等疾病载体的先天免疫力.

科学领域:

免疫学免疫学免疫学
昆虫学昆虫学是一门学科.
寄生虫学的寄生虫学

背景情况:

富含白的重复含有蛋白质对于各种生物体的宿主防御至关重要.
像Anopheles gambiae这样的蚊子是人类重大病原体的载体,包括疟疾寄生虫.

研究的目的:

调查丰富于白的重复含有蛋白质 (LRIM1和APL1C) 在阿诺菲莱斯甘比亚对疟疾免疫力的作用.
阐明这些蛋白质与其他免疫元件相互作用以消除虫寄生虫的机制.

主要方法:

蛋白质组分析以确定Anopheles gambiae hemolymph中的蛋白质复合体.
生物化学试验用于研究蛋白质相互作用和二硫化物桥梁形成.
使用Plasmodium berghei的功能测试来评估寄生虫的向和破坏.

主要成果:

LRIM1和APL1C形成了一个高分子量复合体,由蚊子血淋巴中的二硫化物键稳定.
这种复合物与补充C3样蛋白TEP1相互作用,影响其活性.
LRIM1-APL1C-TEP1相互作用导致TEP1在Plasmodium berghei寄生虫的局部化,标记它们进行破坏.

结论:

LRIM1-APL1C复合体是Anopheles gambiae对疟疾的天生的免疫反应的关键组成部分.
这种蛋白质复合物与TEP1一起,提供了对中肠入侵的Plasmodium寄生虫的重要防御机制.
其他载体蚊子中LRIM1和APL1C的正义学说表明,它们在病原体防御中起着保留的作用.

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