通过环开聚合介导的受控配制的聚甲基药物纳米颗粒
1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Journal of the American Chemical Society
|March 14, 2009
概括
研究人员开发了一种新的方法,使用受控聚合制造来制造多克索鲁比聚胺 (Doxo-PLA) 纳米颗粒. 这种技术允许有效的药物加载和持续释放,为目标药物输送系统提供了一个有希望的方法.
科学领域:
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- doxorubicin (doxo) 是一种强效的化疗药物,但它的使用受到副作用的限制.
- 开发有效的药物输送系统,如纳米粒子,对于向癌症治疗至关重要.
- 聚酸 (PLA) 是一种生物相容的聚合物,通常用于药物输送应用.
研究的目的:
- 开发一种独特的方法来制备多克索鲁比聚丁 (Doxo-PLA) 合纳米粒子 (NC).
- 通过使用一种新的启动器系统,实现乳化物 (LA) 的化学和区域选择性聚合.
- 为了创建具有可控尺寸,药物负载和持续释放特性的Doxo-PLANC.
主要方法:
- 使用了Doxo/(BDI) ZnN ((TMS) ((2) 介导的乳酸 (LA) 的化学和区域选择性聚合物.
- 采用纳米沉来形成Doxo-PLA结合纳米粒子 (NC).
- 研究了固体散体和金属催化剂对聚合选择性和产品形成的影响.
主要成果:
- 实现了近100%的多克索鲁比辛 (Doxo) 负载效率和100%的乳酸盐 (LA) 转化.
- 证明了高的化学选择性,其中1-pyrenemethanol (Pyr-OH) 被消耗并与联,而1-pyrenemethylamine (Pyr-NH) 则保持完整.
- 配制的Doxo-PLANCs尺寸小于150nm和狭窄的颗粒大小分布,表现出持续的Doxo释放而没有突发释放.
结论:
- 开发的Doxo/BDI ZnN TMS 2介导的LA聚合提供了一种可控的方法来制造Doxo-PLA合物.
- 由此产生的纳米颗粒显示出优异的药物载荷,可控制的颗粒大小和持续的药物释放概况.
- 这种多功能方法具有重要的潜力,可以将含酸的剂与聚合物结合,并形成先进的纳米粒子输送系统.
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