一种可生物吸收的常利释放冠状动脉支架系统 (ABSORB):两年的结果和多种成像方法的结果
Patrick W Serruys1, John A Ormiston, Yoshinobu Onuma
1Thorax Center, Erasmus Medical Center, Rotterdam, Netherlands.
Lancet (London, England)
|March 17, 2009
概括
这种可生物吸收的常利脱支架 (BVS) 在两年内证明了安全性和有效性. 它没有显示晚期支架血栓形成,恢复了血管运动,并预防了复原,为金属支架提供了一个有希望的替代方案.
科学领域:
- 心血管医学 心血管医学
- 生物材料科学 生物材料科学
- 干预心脏病学 干预心脏病学
背景情况:
- 金属药物释放支架带来了晚期支架血栓形成等风险,并阻碍了成像.
- 评估可生物吸收冠状动脉支架的安全性和性能至关重要.
研究的目的:
- 评估可生物吸收恒利木斯排泄支架 (BVS) 的两年安全性和临床结果.
- 为了评估支架的生物吸收,血管运动恢复和恢复性预防.
主要方法:
- 一项前性研究跟踪了30名患有单次de-novo冠状动脉病变的患者2年.
- 使用多切片CT,血管造影,血管内超声波 (IVUS) 和光连贯断层扫描 (OCT) 进行全面的成像和分析.
主要成果:
- 在2年内,BVS在临床上是安全的,没有心脏病死亡,支架血栓塞,或缺血症驱动的再血管化.
- 血管造影和IVUS/OCT揭示了持续的静脉支架发光面积,这归因于斑块减少,而不是血管改造.
- 支架的支架显示了回声性和射频反射的降低,在支架的部分观察到恢复了血管运动.
结论:
- 可生物吸收的常利释放支架 (BVS) 在2年内在临床上是安全的,有生物吸收和恢复血管运动的证据.
- 支架有效地预防了复缩,并表明没有晚期血栓形成.
- 需要进一步的研究来证实晚期光扩大是由斑块减少而导致的,而不需要血管改造.
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