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心脏衰竭是因为心脏衰竭
Henry Krum1, William T Abraham
1Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Lancet (London, England)
|March 17, 2009
概括
心力衰竭的管理已经取得了进展,但仍然是一个重大的公共卫生问题. 目前的治疗方法侧重于阻断神经激素系统和管理液体平衡,用于高级阶段的设备.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 尽管有治疗进展,心力衰竭仍然是主要的公共卫生问题,其特点是患病率高,不良临床结果和医疗保健成本高.
- 已确定的HF风险因素是众所周知的,这表明预防策略可以显著降低疾病负担.
- 目前慢性缩性脑膜炎的治疗包括神经激素阻塞 (氨酸-血管氨酸-阿尔多和交感神经系统),以减轻不良的心脏重塑,缓解症状并改善存活率.
研究的目的:
- 审查心力衰竭的当前管理策略,包括药物和基于设备的疗法.
- 要突出治疗急性HF和HF用保存的喷射分数的证据的局限性.
- 探索个性化高频管理的新兴策略,包括新的诊断工具,治疗目标和再生医学方法.
主要方法:
- 对心力衰竭的既定和新兴治疗方法的审查.
- 对管理慢性心衰竭,急性心力衰竭和心力衰竭的当前指导方针的分析.
- 探索新的治疗途径,包括再生医学和个性化治疗方法.
主要成果:
- 慢性静脉动脉的标准治疗包括神经激素抗剂和利尿剂,以及诸如心脏再同步和高级病例的除器植入等设备治疗.
- 支持治疗急性HF和HF的临床证据仍然有限.
- 新兴策略侧重于个性化治疗,先进诊断,新药学点和再生疗法,如基于细胞和基因的方法.
结论:
- 尽管取得了进展,但心力衰竭仍然是一个关键的公共卫生挑战,需要多方面的管理策略.
- 目前的证据缺口需要进一步的研究,特别是对于急性HF和具有保留射出分数的HF.
- 心力衰竭管理的未来方向包括个性化医疗,创新诊断和心脏修复的再生方法.
相关概念视频
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01:26Imbalances in Cardiac Output
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01:29Heart Failure II: Pathophysiology
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