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心周脂肪,胸内脂肪,以及左心室结构和功能的测量:弗雷明汉心脏研究
Caroline S Fox1, Philimon Gona, Udo Hoffmann
1National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA. foxca@nhlbi.nih.gov
Circulation
|March 18, 2009
概括
周心脂肪与心脏结构相关,但其影响与整体肥胖或内脏脂肪并不独立. 肥胖对心脏的系统影响似乎比局部心周脂肪更为显著.
科学领域:
- 心脏病学 心脏病学
- 肥胖问题研究研究
- 医疗成像医学成像
背景情况:
- 心周脂肪与与肥胖有关的心血管疾病有关.
- 心脏脂肪与系统性肥胖影响的独立性需要进一步研究.
研究的目的:
- 探索心周脂肪和心脏结构/功能之间的关联.
- 确定这些关联是否独立于内脏脂肪和整体肥胖.
主要方法:
- 利用了997名弗雷明汉心脏研究参与者的数据 (2002-2005).
- 使用计算机断层扫描 (CT) 来量化心周脂肪,胸内脂肪和内脏脂肪组织 (VAT).
- 使用心血管磁共振成像 (CMR) 来评估左心室 (LV) 质量,LV终端透气体积和左心房尺寸.
主要成果:
- 周心脂肪,胸内脂肪,VAT,BMI和腰围与女性的LV质量和左心房尺寸相关.
- 在男性中,对LV质量和左心房尺寸观察到类似的相关性,但对LV终端透支体积不一致.
- 经过多变量调整后,关联通常仍然存在,但在对体重和增值税进行调整后,除了男性的心周脂肪和左心房尺寸外,这些关联并未存在.
结论:
- 周心脂肪与心脏指标有关,但与其他脂肪储存或肥胖代理无关.
- 系统性肥胖对心脏结构和功能的影响可能比局部心周脂肪更有影响.
- 在男性中,左心房尺寸代表了一个显著的例外,其中心周脂肪关联可能更明显.
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