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在神经发生过程中,DISC1与GSK3beta合作

Guo-li Ming1, Hongjun Song

  • 1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gming1@jhmi.edu

Cell
|March 24, 2009
PubMed
概括

精神分裂症中断1 (DISC1) 蛋白调节神经原始细胞的增殖. 这一发现为遗传易感性如何导致精神疾病提供了新的见解.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...