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Updated: Jun 24, 2026

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
13:02

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO

Published on: December 28, 2019

对于NF-kappaB激活来说,NEMO对线性ubiquitin链的特定识别非常重要

Simin Rahighi1, Fumiyo Ikeda, Masato Kawasaki

  • 1Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki, Japan.

Cell
|March 24, 2009
PubMed
概括

核因子-kappaB基本调节器 (NEMO) 蛋白通过其UBAN动机结合线性泛素链. 这种相互作用对于激活NF-kappaB信号,影响免疫力和解释某些遗传疾病至关重要.

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