一种响应内部和外部球体酸相互作用的PARACEST剂,用于MRI应用
Ching-Hui Huang1, Janet R Morrow
1Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York 14260-3000, USA.
Journal of the American Chemical Society
|March 26, 2009
概括
欧 ((S-THP) 3+ 是一种新型的 PARACEST 剂. 它的MRI对比性取决于pH值,并受到酸盐的影响,显示了响应性成像的潜力.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 化学生物学 化学生物学
- 材料科学 材料科学 材料科学
背景情况:
- 化学交换和转移 (CEST) 剂对MRI至关重要.
- 欧复合物提供了独特的磁性特性,可以增强对比度.
- 开发响应的CEST代理是先进诊断的关键.
研究的目的:
- 要将Eu(S-THP) 3+描述为一种新的PARACEST剂.
- 调查其CEST频谱的pH依赖性和调制.
- 探索其作为响应式MRI对比剂的潜力.
主要方法:
- 欧洲复合物的合成和表征.
- 在水溶液中的CEST光谱学.
- 研究与酸 (二甲基酸盐,甲基酸盐) 的相互作用.
主要成果:
- Eu(S-THP) 3+通过与水交换基质子而起作用.
- CEST频谱对pH非常敏感.
- 酸通过形成外层和内层球体复合体来调节光谱.
- 酒精质子环境对阴离子相互作用很敏感.
结论:
- Eu(S-THP) 3+ 是第一个利用基质子交换的 PARACEST 剂.
- 它的pH依赖和离子调制的CEST光谱显示出响应性.
- 这种复合物显示出作为响应性PARACESTMRI对比剂的显著潜力.
更多相关视频
10:46In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment
Published on: March 16, 2018
08:01Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo
Published on: September 26, 2016
相关概念视频
01:15Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
01:25Applications Of NMR In Biology
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
The...
01:33Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...