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Zc3h12a是一种RNase,通过调节mRNA衰变来控制免疫反应至关重要

Kazufumi Matsushita1, Osamu Takeuchi, Daron M Standley

  • 1Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Nature
|March 27, 2009
PubMed
概括

免疫应答修饰剂 Zc3h12a 是一种必不可少的 RNase,可以预防免疫疾病. 它控制着炎症基因的稳定性,在小鼠中缺乏它会导致严重的贫血和自身免疫症状.

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