阿司匹林,酸盐,以及癌症
Peter C Elwood1, Alison M Gallagher, Garry G Duthie
1School of Medicine, Cardiff University, Cardiff, UK.
Lancet (London, England)
|March 31, 2009
概括
阿司匹林和非类固醇抗炎药物可能会降低大肠癌的风险. 需要进一步的研究来证实这些发现,并探索预防癌症的机制.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学 是一个学科.
- 胃肠病学 胃肠病学
背景情况:
- 观察性研究和动物研究表明,阿司匹林和NSAIDs可能会降低大肠癌的风险.
- 伦理方面的担忧阻止了针对人类癌症预防的大规模随机试验.
研究的目的:
- 总结关于阿司匹林和天然酸盐用于预防癌症的现有证据.
- 讨论潜在的机制和未来的研究方向.
主要方法:
- 审查来自各种来源的证据,包括机会主义试验.
- 对动物研究和人类观察数据的分析.
主要成果:
- 一致的证据表明,阿司匹林和相关的NSAIDs减少了大肠癌的风险.
- 机会主义试验表明,在使用阿司匹林至少10年后,癌症风险降低.
结论:
- 阿司匹林和天然酸盐显示出预防癌症的潜力,特别是大肠癌.
- 需要对机制和临床影响进行进一步的研究.
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