相关实验视频
多种药丸 (Polycap) 对没有心血管疾病 (TIPS) 的中年个体风险因素的影响:第二阶段,双盲,随机试验
Lancet (London, England)
|April 3, 2009
概括
综合药丸Polycap有效降低血压和LDL胆固醇,同时耐受性良好. 这种多药剂配方提供了一种方便的方法来降低心血管风险因素.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病仍然是全球主要的死亡原因.
- 与多种低剂量药物的联合治疗可能提供一种减少心血管事件的策略.
- 多种药丸概念旨在简化药物治疗方案,提高药物的服药度.
研究的目的:
- 为了评估含有低剂量降血压药物,simvastatin和阿司匹林的多药丸 (Polycap) 的疗效和耐受性.
- 评估Polycap对血压,LDL胆固醇,心率和血小板活动的影响.
- 为了比较Polycap与单个成分和其他组合的效果.
主要方法:
- 一个双盲随机试验,涉及2053名45-80岁的参与者,至少有一个心血管风险因素.
- 参与者被分配到Polycap或各种控制组,接受单独的药物或组合.
- 主要结局包括血压,LDL胆固醇,心率,尿路血栓素B2和药物停用率.
主要成果:
- 波利卡普显著降低了7.4毫米升的缩血压和5.6毫米升的腹缩血压.
- 它使LDL胆固醇降低了0.70 mmol/L,心率降低了每分钟7.0次.
- Polycap表现出与单个药物治疗相似的耐受性,基于活性成分数量的不耐受性没有增加.
结论:
- 该Polycap配方有效地减少了多种心血管风险因素.
- 它方便的单片药片形式可以简化治疗,并可能改善坚持.
- 这种多种药丸是减少整体心血管风险的有希望的策略.
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