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Updated: May 5, 2026

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一个突变p53/Smad复合体反对p63以赋予TGFbeta诱导的转移能力

Maddalena Adorno1, Michelangelo Cordenonsi, Marco Montagner

  • 1Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy.

Cell
|April 7, 2009
PubMed
概括

转化生长因子β (TGFbeta) 在晚期癌症中从瘤抑制剂转变为前列腺扩散因子. 突变的p53和Ras瘤基因与TGFbeta合作抑制p63,促进转移.

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