水自组装纳米粒子作为水中的分子受体
Salvador Tomas1, Lilia Milanesi
1School of Biological and Chemical Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK. s.tomas@bbk.ac.uk
Journal of the American Chemical Society
|April 16, 2009
概括
这项研究引入了新的自组装纳米粒子,利用疏水效应增强了连接体结合. 这些人造受体提供了一个稳定的,适应性的平台,用于在水环境中的分子识别.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 人工受体通常使用疏水效应来保持在水中的稳定性.
- 设计刚性框架至关重要,以防止疏水性腔的崩.
- 现有的受体需要特定的结构元素来克服固有的不稳定性.
研究的目的:
- 开发一种新型的人工受体,利用疏水效应在水中自定义其结构.
- 用于从两性构建块中创建稳定,状的聚合物 (纳米颗粒).
- 研究这些自组装纳米粒子的结合特性和潜在应用.
主要方法:
- 两性构建块的设计,其固的胆固醇基疏水分段和Zn-metalloporphyrin头组.
- 这些块的自组装成稳定,状的纳米粒子.
- 在纳米粒子-水接口上对连接体结合亲和力的评估.
- 结合增强剂与八醇/水分区系数 (log P) 的相关性分析.
主要成果:
- 稳定,自组装的纳米粒子形成,持续到纳米分子度.
- 纳米粒子-水接口为具有基本原子的配体提供了特定的结合点.
- 与非自组装受体相比,观察到增强的结合亲和力.
- 结合增强与连接体解解 (log P) 相相关,表明疏水效应是关键.
- 证据表明,多价值效应的证据被观察到与二位基联体显示的亲和力比单位基联体更高.
结论:
- 开发的两构建块自组装成高度稳定的纳米粒子,通过疏水效应来定义它们的结构.
- 这些自我组装的纳米粒子显示出增强的连接体结合亲和力,由溶解和多价值相互作用驱动.
- 该系统可通过不同的两组合来创建差异性受体.
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