在含有thyX基因的生物体中,一种异常的thymidylate生物合成机制

Eric M Koehn1, Todd Fleischmann, John A Conrad

  • 1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.

Nature
|April 17, 2009
PubMed
概括

这项研究揭示了在使用黄素依赖型甲基酸合成酶 (FDTS) 的病原体中发现一种新的甲基酸生物合成途径. 与古典酶不同,FDTS绕过了对活性部位核的需求,为抗生素开发提供了一个新的目标.

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