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相关概念视频

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Free-falling Bodies: Introduction01:07

Free-falling Bodies: Introduction

All objects, neglecting air resistance, fall with the same acceleration towards the Earth's center due to the force exerted by the Earth's gravity. This experimentally determined fact is unexpected because we are so accustomed to the effects of air resistance and friction that we expect light objects to fall slower than heavier ones. People believed that a heavier object had a greater acceleration when falling until Galileo Galilei (1564–1642) proved otherwise. We now know this is not the case.
Free-falling Bodies: Example01:05

Free-falling Bodies: Example

An object falling without any air resistance under the influence of gravitational force is said to be in free-fall. For free-falling bodies, the acceleration due to gravity is constant, irrespective of their mass. Free-fall is experienced not only by objects falling downward, but also by all objects whose motion is influenced by gravitational force alone. The dynamics of free-fall motion can be calculated using kinematic equations of motion, since free-fall acceleration is constant.
The...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...

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Updated: Jun 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

堕落的不朽的人.

Tomek Swigut1, Joanna Wysocka

  • 1Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

Cell
|April 22, 2009
PubMed
概括
此摘要是机器生成的。

体细胞基因表达记忆通过染色体修饰在生殖系中被重置. 组织素脱甲基酶Lsd1/Spr-5可能会在虫中维持生殖细胞的表观遗传稳定性和跨代生存能力.

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相关实验视频

Last Updated: Jun 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 发育生物学 发展生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 体细胞通常在生殖系重编程过程中删除表观遗传记忆.
  • 这个过程涉及到显著的染色质修饰.
  • 维持生殖细胞的表观遗传稳定性对于繁殖成功至关重要.

研究的目的:

  • 为了研究基因组脱甲基酶Lsd1/Spr-5在虫的生殖线表观遗传重置中的作用.
  • 了解Lsd1/Spr-5如何有助于维持生殖细胞表观遗传稳定性和活力.

主要方法:

  • 这项研究可能涉及对模型生物*C. elegans*进行基因分析和分子技术.
  • 研究Lsd1/Spr-5在生殖细胞中的功能.
  • 评估对染色质修饰和表观遗传遗传的影响.

主要成果:

  • 卡茨和其他人. (2009) 表明Lsd1/Spr-5在体质基因表达的生殖系重置中起作用.
  • 这种基因组脱甲基酶似乎参与防止生殖细胞表观遗传稳定性下降.
  • 这些发现表明Lsd1/Spr-5对于确保跨代的生殖细胞活力至关重要.

结论:

  • 基因组脱甲基酶Lsd1/Spr-5参与了生殖线表观遗传重编程的关键过程.
  • Lsd1/Spr-5活动对于维持生殖细胞的表观遗传完整性至关重要.
  • 这种机制确保了表观遗传信息的稳定继承,这对于繁殖成功至关重要.