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一种化学遗传方法,用于产生蛋白激酶的双价抑制剂

Zachary B Hill1, B Gayani K Perera, Dustin J Maly

  • 1Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA.

Journal of the American Chemical Society
|April 28, 2009
PubMed
概括

研究人员开发了一种新的化学遗传方法,用于制造双价激酶抑制剂. 这些抑制剂结合了小分子和,提高了对Src和Abl等蛋白质激酶的强度和选择性.

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