血液透析使用自身组织工程血管移植的有效性:一个多中心队列研究
Todd N McAllister1, Marcin Maruszewski, Sergio A Garrido
1Cytograft Tissue Engineering, Novato, CA, USA.
Lancet (London, England)
|April 28, 2009
概括
这项研究表明,在需要血液透析的高风险患者中,对自身组织工程血管移植的结果很有希望. 这些移植实现了良好的通透率,接近血管接入的临床目标.
科学领域:
- 生物医学工程 生物医学工程
- 血管外科 血管外科
- 再生医学是一种再生医学.
背景情况:
- 小直径血管重建在血管外科手术中至关重要.
- 组织工程血管移植 (TEVGs) 是一个有希望的解决方案.
- 这项研究报告了接受完全生物和自身TEVG的前十名患者.
研究的目的:
- 评估自TEVG在需要血液透析的末期病患者的安全性和有效性.
- 在至少6个月的随访期间,评估移植透度和机械稳定性.
主要方法:
- 招募了10名患有末期脏病和先前访问失败的高风险患者.
- 自主TEVG被培养并植入为动脉静脉突变.
- 在血液透析开始后,对机械稳定性 (0-3个月) 和透气性进行了评估.
主要成果:
- 在最初的安全阶段,有三次移植失败,与这个高风险群体的预期率保持一致.
- 在剩余的8名患者中,有5名患者在植入后6至20个月之间有功能性输血体移植用于血液透析.
- 在可评估患者中,初级通透率在1个月后为78%,在6个月后为60%.
结论:
- 这种高风险队列方法中的初级通透率 透析结果 对动脉静脉的质量倡议目标.
- 自主TEVG显示出在具有挑战性的患者群体中作为血管接入的可行选择的潜力.
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