相关实验视频
Updated: Jun 23, 2026
06:45
Testing Drosophila Olfaction with a Y-maze Assay
Published on: June 12, 2014
选择Drosophila glomeruli通过先天的嗅觉吸引力和厌恶力进行介导
Julia L Semmelhack1, Jing W Wang
1Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.
Nature
|April 28, 2009
概括
果就是一个果.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉加工 嗅觉加工
- 动物行为 动物行为
背景情况:
- 果对食物气味有很强的吸引力,在它们的嗅觉系统中激活了多个淋巴细胞.
- 了解气味表现如何转化为天生的行为对于嗅觉研究至关重要.
研究的目的:
- 调查单个质细胞在调解果对食物气味的天生的吸引力方面的特定作用.
- 为了确定特定的小球体,或整个激活模式,驱动行为反应.
主要方法:
- 在果 (Drosophila melanogaster) 中利用遗传工具来选择性地沉默或激活特定的嗅觉体.
- 通过观察的反应,评估不同度的果对的行为吸引力.
主要成果:
- 低度的果会激活六个质细胞,其中DM1和VA2被认为是吸引力至关重要的.
- 沉默DM1或VA2显著降低了吸引力,而选择性激活这些淋巴细胞恢复了吸引力.
- 较高的度激活了额外的,与减少的吸引力相关,表明行为反应的切换.
结论:
- 个别的质体,特别是DM1和VA2,是果对食物气味的天生的吸引力的关键媒介.
- 特定的淋巴细胞的激活,而不是整体模式,决定了先天的行为输出,以响应嗅觉线索.
相关概念视频
01:20Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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01:25Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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