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Updated: Jun 23, 2026

A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
11:49

A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates

Published on: August 21, 2018

描述集合调制在突变诱导的结合亲和力变化中的作用.

Anthony Manson1, Steven T Whitten, Josephine C Ferreon

  • 1Department of Biochemistry and Molecular Biology, and Sealy Center for Structural Biology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA.

Journal of the American Chemical Society
|April 29, 2009
PubMed
概括

蛋白质的结构波动对于生物功能,如分子识别至关重要. 我们的研究表明,分析这些动态,特别是SH3域,可以准确地预测结合能量,并揭示了蛋白质 - 连接体相互作用的洞察力.

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