在catecholaminergic多态心室性心律失常症中发生心律失常事件的发生率和危险因素
Meiso Hayashi1, Isabelle Denjoy, Fabrice Extramiana
1Service de Cardiologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, INSERM U942, Paris, France.
Circulation
|April 29, 2009
概括
心脏事件是常见的catecholaminergic多形心室性心力衰竭 (CPVT) 患者,即使在β阻塞治疗. 缺少β阻塞剂和诊断时年轻的年龄是这些心律失常的关键风险因素.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学是一种遗传学.
- 电力生理学 电力生理学
背景情况:
- catecholaminergic多形心室性心力衰竭 (CPVT) 是一种由压力引起的心律失常.
- 虽然它的病理生理学已经被理解,但临床特征,事件发生率和风险因素需要进一步阐明.
研究的目的:
- 确定CPVT患者心律失常事件的发生率和危险因素.
- 在长期随访期间分析CPVT患者的结局.
主要方法:
- 在101名CPVT患者 (50名试验者) 的结果分析,平均随访时间为7.9年.
- 评估心脏事件 (昏迷,心脏骤停,心脏突然死亡) 和致命的/接近致命的事件.
- 统计分析以确定事件的独立预测因素.
主要成果:
- 心脏事件的8年事件率为32% (27%与β阻塞剂相比,58%没有).
- 没有β阻塞剂和年轻的诊断年龄是心脏事件的独立预测因素.
- 致命/接近致命事件的8年事件率为13%. 没有β-阻塞剂和先前堕胎的心脏骤停预测了这些事件.
结论:
- 心脏和致命的/接近致命的事件在CPVT患者中并不罕见,即使使用β-阻塞剂.
- 贝塔抑制剂治疗与事件发生率的降低有关.
- 需要对并发治疗进行进一步的研究,以改善CPVT患者的治疗结果.
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