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相关概念视频

Masking and Demasking Agents01:19

Masking and Demasking Agents

EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on the metal...
Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
Buoyancy and Stability for Submerged and Floating Bodies01:11

Buoyancy and Stability for Submerged and Floating Bodies

In fluid mechanics, buoyancy and stability are key concepts for understanding the behavior of submerged and floating bodies. When a stationary body is fully or partially submerged in a fluid, the fluid exerts a force on the body known as the buoyant force. This force acts vertically upward through a point called the center of buoyancy, which is the center of the displaced fluid volume. According to Archimedes' principle, the magnitude of the buoyant force is equal to the weight of the fluid...
Rab Proteins01:14

Rab Proteins

Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Radial System Protection01:23

Radial System Protection

Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...

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相关实验视频

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Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol
09:12

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

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全面 (可切换) 的RAFT代理商.

Massimo Benaglia1, John Chiefari, Yen K Chong

  • 1CSIRO Molecular and Health Technologies, Bag 10, Clayton South, Victoria 3169, Australia.

Journal of the American Chemical Society
|May 1, 2009
PubMed
概括

研究人员开发了新的可切换RAFT剂,用于可控的激素聚合. 这些药物有效地聚合了活性较低的单体和活性较高的单体,使得具有受控分子量的区块共聚合物的合成成为可能.

科学领域:

  • 聚合物化学 聚合物化学
  • 材料科学 材料科学 材料科学

背景情况:

  • 可逆添加碎片化链转移 (RAFT) 是一种受控的激素聚合技术.
  • 为特定的单体 (活性较高与活性较低) 选择合适的RAFT剂对于成功的聚合控制至关重要.
  • 现有的RAFT药物经常表现出选择性,抑制或控制某些单体类型.

研究的目的:

  • 引入一类新的"可切换"RAFT特工.
  • 证明它们在控制低活性单体 (LAM) 和高活性单体 (MAM) 聚合的有效性.
  • 为了能够合成具有受控分子量的块共聚合物.

主要方法:

  • 合成作为可切换的RAFT剂的N-(4-pyridinyl) -N-methyldithiocarbamates. 作为可切换的RAFT剂的N-(4-pyridinyl) -N-methyldithiocarbamates的合成.
  • 使用这些药剂对LAM (例如,乙乙烯) 进行可控的基性聚合.
  • 用蛋白酸或易斯酸激活RAFT剂.
  • 激活后对MAMs (例如,烯酸盐) 的受控基聚合.
  • 合成的多分子 (MAM) - 块的多分子 (LAM) 共聚合物.

主要成果:

  • 新的RAFT剂可以对LAM聚合物进行出色的控制.

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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

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Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

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Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol
09:12

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

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Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

  • 酸激活转化剂以有效控制MAM聚合.
  • 可切换剂允许连续合成区块共聚合物.
  • 由此产生的块共聚物体具有狭窄的分子量分布.

    • 结论:

    • N-(4-pyridinyl) -N-methyldithiocarbamates 是一个多功能类型的可切换RAFT药物.
    • 这些药物克服了传统RAFT药物的单体特异性限制.
    • 它们提供了一个强大的工具,用于高精度合成复杂的聚合物架构,包括块共聚合物.