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Updated: Jun 23, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing
08:50

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

一个cytidine除氨酶编辑C到U在转移RNA在古生物中的编辑

Lennart Randau1, Bradford J Stanley, Andrew Kohlway

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. lennart.randau@yale.edu

Science (New York, N.Y.)
|May 2, 2009
PubMed
概括

超热友的古生物 Methanopyrus kandleri 在tRNA位置8使用cytidine. 研究人员发现了一种cytidine deaminase酶CDAT8,它可以将cytidine编辑成uridine,确保tRNA的正确折叠和功能.

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...