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Updated: Jun 23, 2026

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
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口服的siRNA向巨细胞Map4k4,可以抑制全身炎症

Myriam Aouadi1, Gregory J Tesz, Sarah M Nicoloro

  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Nature
|May 2, 2009
PubMed
概括

研究人员开发了β1,3-D-葡萄糖封装的siRNA颗粒 (GeRPs) 用于口服. 这些GeRP有效地沉默了巨细胞中的基因,为炎症性疾病提供了新的治疗策略.

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