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相关概念视频

DNA Packaging00:58

DNA Packaging

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
DNA Packaging00:58

DNA Packaging

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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相关实验视频

Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

打开了基因组的窗口.

Iestyn Whitehouse1, Toshio Tsukiyama

  • 1Sloan-Kettering Institute, New York, NY 12750, USA. whitehoi@mskcc.org

Cell
|May 5, 2009
PubMed
概括

染色体调节器可以改变基因促进器中核体的位置. 这项研究表明,核细胞的定位如何影响酵母菌的基因调节.

科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 核细胞的定位对于控制基因表达至关重要.
  • 了解染色体结构如何影响转录是一个活跃的研究领域.

研究的目的:

  • 调查染色体调节器在核细胞定位中的作用.
  • 为了证明改变核细胞的定位对Saccharomyces cerevisiae的转录调节的影响.

主要方法:

  • 在基因组中映射核细胞的定位.
  • 分析特定染色体调节剂对基因促进体的影响.

主要成果:

  • 发现一种染色体调节剂改变了许多基因的促进体中的核细胞位.
  • 核酶体定位的这种改变对基因调节有重大影响.

结论:

  • 核细胞的定位是通过染色体修饰剂调节的关键机制.
  • 这项研究突显了核细胞组映射在理解转录控制方面的力量.

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Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

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Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018