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Updated: May 7, 2026

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多个基因的突变导致扩散大B细胞淋巴瘤中NF-kappaB的放松调节

Mara Compagno1, Wei Keat Lim, Adina Grunn

  • 1Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.

Nature
|May 5, 2009
PubMed
概括

NF-kappaB通路调节者的遗传突变,特别是A20基因,在扩散型大B细胞淋巴瘤 (DLBCL) 中很常见. 这些遗传病变导致长时间的NF-kappaB激活,促进淋巴发育.

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