相关实验视频
微专尿和静脉血栓栓塞的风险
Bakhtawar K Mahmoodi1, Ron T Gansevoort, Nic J G M Veeger
1Division of Hemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. b.k.mahmoodi@int.umcg.nl
JAMA
|May 7, 2009
概括
微专尿,内皮功能障碍的标志物,显著增加了静脉血栓栓塞 (VTE) 的风险. 这一发现凸显了监测微专尿对于VTE预防的重要性.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血栓形成研究研究
背景情况:
- 微专 (30-300毫克/24小时) 是动脉血栓栓塞的已知风险标志物.
- 据推测,微专素尿反映了全般的内皮功能障碍,可能使个人易患静脉血栓塞栓症 (VTE).
研究的目的:
- 调查微专尿与发展VTE的风险之间的关联.
- 为了确定微专尿是否是VTE的独立风险因素.
主要方法:
- 基于社区的前性队列研究 (PREVEND) 始于1997年.
- 纳入8592名参与者,详细的查数据包括尿路白蛋白分泌 (UAE) 和心血管风险因素.
- 对客观验证的VTE事件的随访,平均时间为8.6年.
主要成果:
- 观察到VTE发病率的增加趋势,阿联水平较高 (P<.001).
- 患有微专尿的参与者 (UAE 30-300 mg/24h) 患有静脉瘤的风险增加了2.00倍 (调整HR 2.00;95% CI,1.34-2.98).
- 较高的阿联水平 (>300毫克/24小时) 显示2.82倍的风险增加 (调整HR2.82;95%CI,1.21-6.61).
结论:
- 微专尿与静脉血栓栓塞的显著增加风险独立相关.
- 这些发现表明,微蛋白尿可能成为评估VTE风险的有价值生物标志物.
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