在一般人群中,肺动脉静脉压与年龄相关的增加
Carolyn S P Lam1, Barry A Borlaug, Garvan C Kane
1Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Circulation
|May 13, 2009
概括
肺动脉静脉压 (PASP) 随着年龄的增长而增加,并与较高的死亡风险有关. 这项研究强调了PASP作为潜在的心血管风险因素和一般人群的治疗目标.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 肺部病理学 肺部病理学
背景情况:
- 关于肺动脉抽缩压 (PASP) 与年龄相关的变化及其对一般人群的预后影响的数据有限.
- 对老年人系统性静脉压高的研究丰富,但对肺循环变化的理解较少.
- 这项研究旨在调查PASP与衰老之间的关系,确定其影响因素,并评估其对死亡率的预测价值.
研究的目的:
- 定义肺动脉抽缩压 (PASP) 与一般人群年龄之间的关系.
- 确定影响PASP的因素.
- 为了确定PASP是否是死亡率的独立预测因素.
主要方法:
- 来自明尼苏达州奥尔姆斯特德县的2,042个人的随机样本接受了心声回声和螺旋计.
- 肺动脉缩压 (PASP) 用三管吐速度进行测量.
- 还评估了左心室透气压 (通过E/e'比率估计) 和动脉硬度 (臂动脉脉冲压).
主要成果:
- 在1413名具有可测量的PASP的受试者中,PASP的中位数为26 mm Hg,并且随着年龄的增长而增加 (r=0.31,P<0.001).
- 独立的PASP预测因素包括年龄,脉冲压,和心肌E/e' (P<或=0.003).
- 增加PASP与较高的死亡率 (HR,2.73每10mmHg;P<0.001) 显著相关,即使在没有先前存在心肺疾病的受试者中也是如此.
结论:
- 这项研究提供了第一个基于人口的证据,证明肺动脉压力与年龄相关的增加.
- 升高的肺动脉压力与左心脏扩张压力增加和全身血管硬化有关.
- 肺动脉压力成为一种新的心血管风险因素,有可能成为治疗点.
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