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通过溶液NMR光谱学在膜环境中的老鼠小岛粉样蛋白多蛋白的三维结构和方向

Ravi Prakash Reddy Nanga1, Jeffrey R Brender, Jiadi Xu

  • 1Department of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Journal of the American Chemical Society
|May 22, 2009
PubMed
概括

鼠岛粉样蛋白聚 (IAPP) 形成螺旋结构,但与人类IAPP不同,它不是有毒的粉样蛋白纤维. 这项研究揭示了老鼠的IAPP.

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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...