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DNA的自我组装成纳米级的三维形状

Shawn M Douglas¹, Hendrik Dietz, Tim Liedl

¹Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

|May 22, 2009

概括

研究人员开发了一种DNA自组装方法,以创建精确的3D纳米结构. 这种可编程技术可以制造具有可控尺寸的复杂纳米设备.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

分子自我组装使得以亚纳米准确度的自下而上的制造成为可能.
DNA是构建二维晶体和三维纳米多面体等纳米物体的多功能构建块.
之前的方法证明了DNA自组装成2D形状,使用脚手架和主丝.

研究的目的:

扩展DNA自组装方法,以创建定制的三维 (3D) 纳米结构.
为了展示各种3D形状的设计和组装,控制尺寸.
探索复杂的DNA纳米结构的层次组合.

主要方法:

使用模板自组装方法,使用DNA支架和主链.
扩展2D DNA原木方法来创建3D结构,形成在蜂巢格子上曲的螺旋体层.
优化折叠时间和阴离子度 (单价和双价) 进行正确的组装.

主要成果:

成功设计并组装了六个定制的3D纳米结构:单立体,方形坚果,轨道桥,精灵瓶,堆叠十字架和槽式十字架.
实现了对纳米结构尺寸的精确控制,范围从10到100纳米.
展示了线性轨道和电缆框架icosahedra的等级组装.

结论:

开发的DNA自组装策略使得以纳米级精度制造定制的3D纳米结构成为可能.
这种方法为制造具有纳米尺度特征的复杂设备提供了一条通道.
DNA自组装的可编程性为先进的纳米级工程和设备制造开辟了道路.

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