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Updated: Jun 23, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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1,3-二极性化物对应力基和基的循环添加中的反应性和区域选择性:一项计算研究

Franziska Schoenebeck1, Daniel H Ess, Gavin O Jones

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|May 23, 2009
PubMed
概括

本研究使用计算方法探索1,3-双极循环加法. 环基因比环基因更具反应性,反应性受环形大小和替代剂的影响.

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Halogenation is another class of electrophilic addition reactions where a halogen molecule gets added across a π bond. In alkynes, the presence of two π bonds allows for the addition of two equivalents of halogens (bromine or chlorine). The addition of the first halogen molecule forms a trans-dihaloalkene as the major product and the cis isomer as the minor product. Subsequent addition of the second equivalent yields the tetrahalide.
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If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
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