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快乐小时,一个Ste20家族激酶,涉及EGFR信号在乙醇诱导的行为
Ammon B Corl1, Karen H Berger, Galit Ophir-Shohat
1Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143-2822, USA.
Cell
|May 26, 2009
概括
研究人员发现了一种基因,快乐时刻,影响乙醇敏感性. 抑制EGF受体通路显示出治疗饮酒障碍 (AUD) 的潜力.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 药理学 药理学 是一个学科.
背景情况:
- 酒精使用障碍 (AUD) 有严重的后果,但有效的治疗方法有限.
- 识别乙醇行为影响的遗传调节者对于开发新疗法至关重要.
研究的目的:
- 通过Drosophila的遗传选,识别参与调节乙醇行为影响的基因.
- 研究快乐时刻 (hppy) 基因和表皮生长因子 (EGF) 信号通路在乙醇敏感性中的作用.
主要方法:
- 在Drosophila中进行了基因选,以确定具有改变乙醇敏感性的突变物.
- 描述了快乐时刻 (hppy) 突变及其蛋白质产物.
- 利用遗传和生化实验来阐明EGF途径的作用.
- 在,小鼠和老鼠中进行了EGF受体 (EGFR) 的药理抑制.
主要成果:
- 确定了快乐时刻 (hppy) 突变体,对乙醇镇静作用的抵抗力增加.
- Hppy蛋白与哺乳动物的Ste20家族激酶是同源的.
- EGF信号通路调节了Drosophila的乙醇敏感性,而Hppy则作为一种抑制剂.
- 药理上EGFR抑制改变了和小鼠的乙醇敏感性,并减少了老鼠的乙醇消耗.
结论:
- EGF信号通路是乙醇敏感性的关键调节器.
- 抑制EGFR或其途径组件为AUDs提供了一个潜在的治疗策略.
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