相关实验视频
塔达拉菲尔治疗肺动脉高血压的治疗方法
Nazzareno Galiè1, Bruce H Brundage, Hossein A Ghofrani
1Institute of Cardiology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. nazzareno.galie@unibo.it
Circulation
|May 28, 2009
概括
塔达拉菲尔是一种固酶-5型抑制剂,可显著改善肺动脉高血压患者的运动能力. 达拉菲尔的40毫克剂量耐受良好,并减少了临床恶化.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 药理学 药理学 是一个学科.
背景情况:
- 目前的肺动脉高血压治疗针对的是前环素,内甲素或氧化通路.
- 塔达拉菲尔是一种固酶-5型抑制剂,通过增加cGMP来增强氧化路径.
研究的目的:
- 评估tadalafil在患有肺动脉高血压的患者中的疗效和安全性.
- 评估塔达拉菲尔对运动能力,临床恶化和生活质量的影响.
主要方法:
- 一项为期16周,双盲,安慰剂控制的研究,涉及405名肺动脉高血压患者.
- 患者每天接受安慰剂或塔达拉菲尔 (2.5,10,20或40毫克) 口服一次.
- 主要终点是6分钟步行距离的变化;次要终点包括世界卫生组织的功能类,临床恶化和生活质量.
主要成果:
- 塔达拉菲尔在6分钟的步行距离中表现出剂量依赖的改善,40毫克的剂量达到统计学意义 (P<0.01).
- 40毫克的塔达拉菲尔剂量改善了临床恶化的时间和发病率,并改善了与健康有关的生活质量.
- 常见的不良事件包括头痛,肌痛和发红; 塔达拉菲尔一般耐受良好.
结论:
- 达拉菲尔40毫克在改善肺动脉高血压患者的运动能力和生活质量方面是有效的.
- 塔达拉菲尔40毫克可以降低这种患者群体临床恶化的风险.
- 塔达拉菲尔是肺动脉高血压的耐受性良好的治疗选择.
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