患有肥胖和与肥胖相关的2型糖尿病的年轻人表现出动脉结构和功能的异常
Elaine M Urbina1, Thomas R Kimball, Connie E McCoy
1Department of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati, OH 45229, USA. Elaine.Urbina@cchmc.org
Circulation
|May 28, 2009
概括
患有肥胖或2型糖尿病的年轻人表现出动脉厚度和硬度增加,表明早期心血管风险. 这些变化凸显了早期干预的必要性,以防止中风和心脏病发作.
科学领域:
- 心血管健康 心血管健康
- 儿科内分泌学 儿科内分泌学
- 血管生物学 血管生物学
背景情况:
- 肥胖或2型糖尿病 (T2DM) 的成年人面临中风和心肌梗塞的风险增加.
- 动脉内心介质厚度增加 (cIMT) 和动脉硬与这些不良心血管结果有关.
- 这项研究调查了患有瘦身,肥胖或T2DM疾病的青少年的动脉特征.
研究的目的:
- 为了比较瘦,肥胖和T2DM年轻人的动脉结构和度.
- 在这些群体中确定动脉内膜厚度和硬度的决定因素.
- 评估儿童肥胖和T2DM的早期血管变化.
主要方法:
- 带超声波用于测量182名瘦身者,136名肥胖者和128名T2DM年轻人 (10-24岁) 的cIMT.
- 计算的指标包括Young弹性模量和β度指数.
- 评估了人体测量,实验室值,血压和心血管风险因素.
主要成果:
- 肥胖和T2DM年轻人与瘦年轻人相比,表现出较大的动脉内膜介质厚度 (cIMT).
- 在肥胖和T2DM群体中,动脉比瘦肉对照群体显著更为硬.
- 心血管风险因素逐渐恶化,从瘦身到肥胖到T2DM群体.
结论:
- 患有肥胖和T2DM的年轻人呈现出异常的动脉厚度和硬度.
- 这些血管异常只能部分由传统的心血管风险因素解释.
- 早期发现和管理心血管风险因素对于这些年轻人来说至关重要,以防止未来的中风和心肌梗塞.
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