相关实验视频
Updated: Jan 13, 2026
01:29
Endocarditis IV: Nursing Management
Published on: June 19, 2025
314
使用抑制酸性药物和在医院获得肺炎的风险
Shoshana J Herzig1, Michael D Howell, Long H Ngo
1Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA. sherzig@bidmc.harvard.edu
JAMA
|May 28, 2009
概括
使用抑制酸性药物,包括质子抑制剂,与患者在医院获得的肺炎风险增加30%有关. 这种关联凸显了这些常见的处方药在住院治疗环境中的潜在风险.
科学领域:
- 药学流行病学 药学流行病学
- 传染病流行病学 传染病流行病学
- 医院的安全 医院的安全
背景情况:
- 抑制酸性药物的使用正在增加,特别是在医院.
- 许多患者接受这些药物没有明确的指示.
- 这些药物的潜在不良影响需要调查.
研究的目的:
- 调查抑制酸性药物和医院获得的肺炎 (HAP) 之间的关联.
- 用于量化使用质子抑制剂 (PPI) 或组胺基因2受体对抗剂 (H2RAs) 的患者的HAP风险.
主要方法:
- 对超过63,000例住院病人的前性队列研究.
- 定义了作为PPI或H2RA订单的抑制酸性药物的使用.
- 使用多变量逻辑回归和倾向得分匹配以控制混因子.
- 使用ICD-9-CM代码识别的HAP.
主要成果:
- 医院获得的肺炎发生在3.5%的入院患者中.
- 使用抑制酸性药物与HAP的几率增加30%有关 (调整后OR,1.3;95% CI,1.1-1.4).
- 对于质子抑制剂而言,增加的风险是显著的,但不是组胺2受体对抗剂.
结论:
- 抑制酸性药物的使用与在医院获得的肺炎的发病率较高有关.
- 特别是质子抑制剂,显示出与增加HAP风险的统计学显著关联.
- 研究结果表明,需要重新评估住院患者常规使用抑制酸性药物的必要性.
相关概念视频
Myocarditis III: Medical Management
168
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
168
Endocarditis IV: Nursing Management
314
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
314
Endocarditis I: Introduction
382
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
382
Increased Body Temperature
6.4K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Methods of reducing fever
1.2K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
1.2K
Homeostatic Imbalances in Body Temperature
4.3K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.3K