一种异金属的Ga/Yb-Schiff基复合物,用于催化不对称的异化物对化物的α-添加
Hisashi Mihara1, Yingjie Xu, Nicholas E Shepherd
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
一种新型的异金属复合物促进了异化物对化物进行不对称的α-添加. 这种新的催化剂可以实现对各种化物基质的高反选择性.
科学领域:
- 有机金属化学 有机金属化学
- 不对称的催化剂.
- 有机合成 有机合成
背景情况:
- 希夫基联体在协调化学中具有多样性.
- 双金属催化提供了独特的反应性和选择性.
- 稀土金属三叶酸具有适合催化的易斯酸性.
研究的目的:
- 开发一种用于不对称催化物的新型异金属复合物.
- 为了研究Ga(O-iPr) 3/Yb(OTf) 3/Schiff基2d复合物的α-添加的疗效.
- 为了探索催化剂与各种化物基质的作用范围.
主要方法:
- 由o-vanillin衍生出的希夫基联体的合成.
- 使用Ga(O-iPr) 3和Yb(OTf) 3.使用异金属复合物的形成.
- 复合物的应用在催化不对称的alpha-additions中,将alpha-isocyanoacetamides添加到aldehydes中.
主要成果:
- 希夫基2d连接体有效地与阴离子稀土金属三酸盐协调.
- 该Ga(O-iPr) 3/Yb(OTf) 3/Schiff基2d复合物催化了反应,具有良好的至优秀的反选择性 (88-98% ee).
- 催化剂证明了与,异,和甲基化的有效性.
结论:
- 基于希夫基催化的一种新型异金属复合物的成功开发.
- 开发的催化剂对异化物对广泛的化物进行不对称的α添加有效.
- 这项工作扩大了双金属稀土金属催化在选合成中的实用性.
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