阴离子触发的药物从一个多孔的-亚丁酸盐金属有机框架释放
Jihyun An1, Steven J Geib, Nathaniel L Rosi
1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
Journal of the American Chemical Society
|June 4, 2009
概括
研究人员开发了生物MOF-1,一种新的金属有机框架使用腺素. 这种材料显示出控制药物释放的潜力,缓冲子影响药物化.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 金属有机框架 (MOF) 为各种应用提供可调节的多孔性.
- 生物分子构建块可以赋予MOFs独特的特性.
- 控制的药物输送系统对于治疗疗效至关重要.
研究的目的:
- 为了合成和表征一种新的MOF,生物MOF-1,使用腺素.
- 评估生物MOF-1在生物条件下的多孔性和稳定性.
- 调查生物-MOF-1对可控药物释放的潜力,以检测胺HCl的释放.
主要方法:
- 使用腺因作为生物分子链接器合成生物MOF-1.
- 孔隙性和表面积分析.
- 在各种生物缓冲中进行稳定性测试.
- 通过与益卡因胺 HCl.的阴离子交换来进行药物加载.
- 在体外药物释放研究.
主要成果:
- 生物MOF-1已成功合成为一个多孔的阳离子框架.
- 该材料在相关的生物缓冲区中表现出稳定性.
- 甲胺HCl被有效地装入生物MOF-1孔.
- 普罗卡因胺HCl的释放动力学受到缓冲区中存在的外源离子的影响.
结论:
- 生物MOF-1代表了一种有前途的基于生物分子的MOF用于药物输送.
- 该框架的药物释放概况对生理缓冲条件敏感.
- 进一步的研究可以优化生物MOF-1用于有针对性和受控的治疗应用.
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